Given below are two statements, one is labelled as Assertion (A) and other one labelled as Reason (R):
In light of the above statements, choose the correct answer from the options given below:
नीचे दो कथन दिए गए हैं, एक को अभिकथन (A) और दूसरे को कारण (R) के रूप में लेबल किया गया है:
उपरोक्त कथनों के आलोक में, नीचे दिए गए विकल्पों में से सही उत्तर चुनिए:
Penetrance, Expressivity, and Genotype Elucidation:
- Assertion (A) is TRUE: When individuals with the exact same genotype fail to show the trait (incomplete penetrance) or express it with varying degrees of severity (variable expressivity) due to modifier genes and environmental fluctuations, a simple 1-to-1 correspondence between genotype and phenotype breaks down, confounding phenotypic selection.
- Reason (R) is TRUE and correctly explains (A): Because individual phenotype cannot reliably reveal the underlying genotype in the presence of incomplete penetrance, multi-generational progeny testing is required to observe segregation patterns across large offspring populations and conclusively verify whether non-expressing or mildly-expressing individuals actually carry the mutant allele.
विस्तृत व्याख्या:
Penetrance, Expressivity, and Genotype Elucidation (प्रवेश्यता एवं संतति परीक्षण):
- Assertion (A) is TRUE: When individuals with the exact same genotype fail to show the trait (incomplete penetrance) or express it with varying degrees of severity (variable expressivity) due to modifier genes and environmental fluctuations, a simple 1-to-1 correspondence between genotype and phenotype breaks down, confounding phenotypic selection.
- Reason (R) is TRUE and correctly explains (A): Because individual phenotype cannot reliably reveal the underlying genotype in the presence of incomplete penetrance, multi-generational progeny testing is required to observe segregation patterns across large offspring populations and conclusively verify whether non-expressing or mildly-expressing individuals actually carry the mutant allele.