Q.3
Given below are two statements regarding protein structure prediction methods
Statement (I) : Ab initio method predicts protein structures based on sequence homology with known structures
Statement (II) : Homology modeling, also known as comparative modeling attempts to produce all-atom protein models based
on sequence information alone without the aid of known protein structures.
In light of the above statements, choose the most appropriate answer from the options given below.
EXPLANATION
Quantitative Genetics: Variance Partitioning, Heritability, Repeatability, Path Analysis & Selection Indices
- Protein Structure Prediction Paradigms:
- Statement (I): Ab initio method predicts protein structures based on sequence homology with known structures. $\implies$ False.
- Ab initio (de novo) structure prediction predicts 3D tertiary structure from physicochemical principles and amino acid sequences without using known homologous template structures.
- Statement (II): Homology modeling, also known as comparative modeling attempts to produce all-atom protein models based on sequence information alone without the aid of known protein structures. $\implies$ False.
- Homology (comparative) modeling constructs models strictly dependent on experimentally resolved 3D structures (templates from PDB) sharing significant sequence similarity.
- The definitions in the two statements are mutually inverted.
- Conclusion: Both Statement (I) and Statement (II) are false (Option 2).
Correct option: (2) Both Statement (I) and Statement (II) are false.
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