9
Given below are two statements regarding substitution matrices
Statement (I) : The PAM substitution matrices were derived using local multiple alignments.
Statement (II) : The BLOSUM matrices were derived using substitution frequencies derived from sets of closely related
protein sequences.
In light of the above statements, choose the most appropriate answer from the options given below.
EXPLANATION
Probability Theory, Random Variables, Expecta
- PAM vs. BLOSUM Substitution Matrices:
- Statement (I): The PAM substitution matrices were derived using local multiple alignments. $\implies$ Incorrect.
- PAM (Point Accepted Mutation) matrices (Dayhoff et al., 1978) were derived from global alignments of closely related protein sequences with >85% identity.
- Statement (II): The BLOSUM matrices were derived using substitution frequencies derived from sets of closely related protein sequences. $\implies$ Incorrect.
- BLOSUM (Blocks Substitution Matrix) matrices (Henikoff & Henikoff, 1992) were derived from local multiple alignments of conserved ungapped blocks (BLOCKS database) representing moderately to distantly related proteins (e.g., BLOSUM62 clusters sequences sharing 62% identity or greater).
- Conclusion: Both Statement (I) and Statement (II) are incorrect (Option 2).
Correct option: (2) Both Statement (|) and Statement (II) are incorrect
Explanation not matching this question?
क्या व्याख्या इस प्रश्न से मेल नहीं खा रही?
Report
Want to practice this paper in exam conditions?
क्या आप परीक्षा जैसे माहौल में अभ्यास करना चाहते हैं?
Test yourself in 5-question batch format with timer and hidden answers.
5-प्रश्नों के बैच फॉर्मैट, टाइमर और छिपे उत्तरों के साथ खुद को परखें।
Start Practice Mode →
प्रैक्टिस टेस्ट मोड शुरू करें →