• Identifying Confounded Factorial Interactions from Layout:
• In a $2^4$ factorial experiment with 2 blocks per replication, the interaction confounded corresponds to the defining contrast linear combination $L = \sum \alpha_i x_i \pmod 2$.
• Replication I Analysis:
• Check Block 1 treatments: 0000, 0011, 0101, 0110, 1001, 1010, 1100, 1111.
• Sum of all four coordinates: $L = x_1 + x_2 + x_3 + x_4 \pmod 2$.
• $0+0+0+0 = 0$
• $0+0+1+1 = 0$
• $0+1+0+1 = 0$
• $0+1+1+0 = 0$
• $1+0+0+1 = 0$
• $1+0+1+0 = 0$
• $1+1+0+0 = 0$
• $1+1+1+1 = 0$
• All units in Block 1 yield $L \equiv 0 \pmod 2$, whereas units in Block 2 yield $L \equiv 1 \pmod 2$. Thus, ABCD is confounded in Replication I.
• Replication II Analysis:
• Check Block 1 treatments: 0000, 0001, 0110, 0111, 1010, 1011, 1100, 1101.
• Sum of first three coordinates: $L = x_1 + x_2 + x_3 \pmod 2$.
• All units in Block 1 yield $x_1 + x_2 + x_3 \equiv 0 \pmod 2$, whereas units in Block 2 yield $x_1 + x_2 + x_3 \equiv 1 \pmod 2$.
• Thus, ABC is confounded in Replication II.
• Conclusion: ABCD in Replication I and ABC in Replication II (Option 4).

Correct option: (4) ABCD in Replication | and ABC in Replication II