Human Chorionic Gonadotropin (hCG): A glycoprotein hormone composed of two non-covalently linked glycosylated polypeptide subunits ($\alpha$ and $\beta$).
In fish reproduction, hCG acts as an effective luteinizing hormone (LH) analog, binding directly to ovarian and testicular gonadotropin receptors to trigger final oocyte maturation, ovulation, and spermiation during induced breeding.
Correct Option: Option 2 (Glycoprotein).
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In cyprinid and catfish reproduction, dopamine exerts a potent inhibitory tone on pituitary gonadotropin release by binding to pituitary dopamine $D_2$ receptors.
Pimozide (and Domperidone): Potent dopamine $D_2$ receptor antagonists that bind to dopamine receptors and block the inhibitory action of dopamine, allowing endogenous or exogenous GnRH to stimulate massive LH release.
Correct Option: Option 4 (Pimozide).
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4
ICAR JRF Aquaculture 29 Jun 2024Shift 1
MCQ (Single Correct)+4−1
Gonadotropin-releasing hormone is responsible for the
Gonadotropin-Releasing Hormone (GnRH): A decapeptide hormone synthesized in the preoptic-hypothalamic area of the brain.
It acts on pituitary gonadotropes to stimulate both the release of Follicle-Stimulating Hormone (FSH / GtH-I) and the release of Luteinizing Hormone (LH / GtH-II).
Both 1 and 2 are direct actions of GnRH.
Correct Option: Option 4 (1 & 2).
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Developed by Dr. H.R. Lin and Dr. Richard Peter (1986), the Linpe Method revolutionized induced breeding of recalcitrant fishes (carps and catfishes).
It involves co-injecting a potent synthetic LHRH analogue (GnRH-a, e.g., $[\text{D-Ala}^6, \text{Pro}^9\text{-NEt}]\text{-LHRH}$) combined with a Dopamine Antagonist (such as pimozide or domperidone) to overcome endogenous dopaminergic inhibition.
Correct Option: Option 1 (LH-RH-a (GnRH-a) and a dopamine antagonist).
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