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Given below are two statements
Statement (I) : During feedback inhibition of enzyme, the activity of an enzyme already present in the cell and it is inhibited by
the end product of the reaction
Statement (II) : During repression of enzyme, the synthesis of an enzyme is inhibited by the end product of the reaction
In light of the above statements, choose the most appropriate answer from the options given below.
EXPLANATION
Enzyme Catalysis, Kinetics, Allostery, & Mech
- Statement (I) is True: During feedback inhibition (allosteric inhibition), the end-product of a biosynthetic pathway binds to an allosteric regulatory site of an early pathway enzyme already present in the cell, rapidly suppressing its catalytic activity post-translationally.
- Statement (II) is True: During enzyme repression, the accumulating end-product acts as a corepressor, binding to an aporepressor to form an active repressor that silences promoter transcription, thereby shutting down the de novo synthesis of the enzyme at the genetic level.
- Conclusion: Both Statement (I) and Statement (II) are true.
Correct option: (1) Both Statement (I) and Statement (II) are true.
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