Q72: Which of the following bacterial pathogens causes Guillain-Barre Syndrome through... - Microbiological Quality of Milk - Dairy Microbiology- ICAR JRF/SRF 2024 | Agrigyan

• Campylobacter jejuni and Guillain-Barré Syndrome (GBS):
• Pathogen Characteristics:
• Campylobacter jejuni is a microaerophilic, curved Gram-negative motile bacterium shed by dairy cattle and transmitted via consumption of raw, unpasteurized milk.
• Pathogenesis of GBS:
• It is the leading antecedent trigger of Guillain-Barré Syndrome (GBS), an acute autoimmune polyneuropathy characterized by ascending motor paralysis.
• Arises from molecular mimicry: Antibodies directed against the core lipooligosaccharide (LOS) of C. jejuni cross-react with human peripheral nerve gangliosides (GM1, GD1a), causing autoimmune demyelination.
• Conclusion: Campylobacter jejuni (Option 3).

Correct option: (3) Campylobacter jejuni