Q.6
Fish Biotechnology- ICAR JRF/SRF 2024 (Q.95)
MCQ (Single Correct)
+4
−1
Co-translational targeting occurs in
EXPLANATION
Protein Engineering, Disulphide Bond Reduction (DTT, BME) and Co-Translational Protein Targeting
- Protein Translocation Mechanisms:
- Post-Translational Targeting: Polypeptides are fully synthesized on free cytosolic ribosomes before import into mitochondria, peroxisomes, and the nucleus.
- Co-Translational Targeting:
- Polypeptides bearing an N-terminal hydrophobic signal peptide are recognized during translation by the Signal Recognition Particle (SRP).
- SRP pauses translation and docks the ribosome-nascent chain complex onto the translocon (Sec61) on the Rough Endoplasmic Reticulum (RER) membrane.
- Synthesis resumes directly through the membrane pore into the ER lumen, moving sequentially through the Golgi complex via vesicular transport.
- nalysis:
- (Golgi complex / ER-Golgi secretory pathway): Correct.
Correct option: (4) Golgi complex
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