Q.10
C-reactive protein was named because of its reactivity with one of the following residues of the C-polysaccharide of the
teichoic acid of pneumococcal bacteria
- Origin and Nomenclature of C-Reactive Protein:
- Discovered in 1930 by Tillett and Francis, CRP is a prototypical acute-phase pentraxin protein of the innate immune system present in vertebrates, including fishes.
- It was originally named for its ability to form a precipitate in the presence of $Ca^{2+}$ with the "Fraction C" polysaccharide (C-substance, a teichoic acid) extracted from the cell wall of Streptococcus pneumoniae.
- Subsequent biochemical research revealed that CRP specifically binds to the phosphocholine (phosphorylcholine / phosphatidylcholine) headgroup of this C-polysaccharide and exposed cell membrane phospholipids.
- nalysis:
- (Phosphatidylcholine / Phosphocholine): Correct.
Correct option: (4) Phosphatidylcholine
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