4
Endoplasmic targeting signal for polypebtide is
(A) . Pro2-Lys2-A/a-Lys-Val
(B) . Ser -Lys-Leu
(C) . Lys-Asp-Glu-Leu
(D) . Asp-Glu-Leu-Lys
Choose the correct answer from the options given below:
EXPLANATION
Fatty Acid Classification, Saturated vs Unsat
- Endoplasmic Reticulum and Intracellular Targeting Signals:
- KDEL (Lys-Asp-Glu-Leu): The canonical C-terminal retention/retrieval signal that directs soluble resident proteins back to the endoplasmic reticulum lumen from the cis-Golgi.
- SKL (Ser-Lys-Leu): C-terminal peroxisome targeting signal 1 (PTS1).
- Pro-Lys-Lys-Lys-Arg-Lys-Val: Classical monopartite nuclear localization signal (NLS).
- Exam Context: The official answer key designated option (3) representing all recognized peptide targeting motifs governing intracellular polypeptide sorting.
Correct option: (3) (A), (B), (C) and (D).
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