8
The anticoagulant which can inhibit glycolysis is
EXPLANATION
Glycolytic Pathway, Pyruvate Oxidation & Aero
- Glycolysis Inhibition by Fluoride: Sodium Fluoride (NaF) is the anticoagulant and preservative of choice in blood tubes used for plasma glucose determination.
- Mechanism of Action: Fluoride ions ($F^-$) bind inorganic phosphate and magnesium to form a magnesium fluorophosphate complex that strongly inhibits enolase (phosphopyruvate hydratase), blocking the dehydration of 2-phosphoglycerate to phosphoenolpyruvate ($2\text{-PGA} \to \text{PEP}$).
- Preservation: This halts in vitro glycolysis by erythrocytes and leukocytes, preventing artificial decline in measured blood glucose levels.
Correct option: (3) Sodium Fluoride
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