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Dual vaccine candidate against ticks is:
EXPLANATION
Antiparasitic Vaccines & Concealed Antigens
- Dual-Action Tick Vaccine: 64 TRP (64-kDa Tick Recombinant Protein) is a truncated cement-cone salivary protein originally cloned from Rhipicephalus appendiculatus.
- Mechanism of Action: It acts as a dual-target vaccine candidate: (1) It damages the tick attachment cement cone, inducing local inflammatory rejection and disrupting blood feeding and reproduction across multiple ixodid species (Rhipicephalus, Amblyomma, Ixodes); (2) It cross-protects against transmission of tick-borne pathogens, notably tick-borne encephalitis virus (TBEV).
- Other Tick Antigens:
- Bm86 & Bm91: Concealed gut antigens from Rhipicephalus (Boophilus) microplus used in commercial anti-tick vaccines (TickGARD, Gavac), which damage gut digestive cells rather than acting as dual transmission-blocking cement targets.
Correct option: (3) 64 TRP.
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