Given below are two statements, one is labelled as Assertion (A)...

Q.1

Veterinary Pharmacology and Toxicology- ICAR JRF/SRF 2024 (Q.76)

Assertion & Reason +4 −1

Given below are two statements, one is labelled as Assertion (A) and other one labelled as Reason (R)

Assertion (A) : Fluoroquinolones are not recommended for young and growing animals.

Reason (R) : The mechanism for damage to the cartilage is via the chelation of magnesium by the drug leading to vesiculation of the articular surface. Chelation of the magnesium results in a local magnesium deficiency, leading to loss of proteoglycan in the articular cartilage

In light of the above statements, choose the correct answer from the options given below.

Both (A) and (R) are true and (R) is the correct explanation of (A) Both (A) and (R) are true but (R) is NOT the correct explanation of (A). (A) is true but (R) is false. (A) is false but (R) is true.

Q.2

Veterinary Pharmacology and Toxicology- ICAR JRF/SRF 2024 (Q.77)

Assertion & Reason +4 −1

Given below are two statements, one is labelled as Assertion (A) and other one labelled as Reason (R).

Assertion (A) : Combinations with other antibiotics may antagonize the antimicrobial effects of fluoroquinolones.

Reason (R) : Other antibiotics do not produce a synergistic effect when administered with fluoroquinolones

In light of the above statements, choose the correct answer from the options given below.

Both (A) and (R) are true and (R) is the correct explanation of (A) Both (A) and (R) are true but (R) is NOT the correct explanation of (A). (A) is true but (R) is false (A) is false but (R) is true.

Q.3

Veterinary Pharmacology and Toxicology- ICAR JRF/SRF 2024 (Q.78)

Statement Based +4 −1

Given below are two statements

Statement (I) : Enrofloxacin is not approved for lactating cattle

Statement (II) : Enrofloxacin is highly excreted in milk.

In light of the above statements, choose the most appropriate answer from the options given below.

Both Statement (I) and Statement (I) are correct Both Statement (I) and Statement (Il) are incorrect Statement (I) is correct but Statement (II) is incorrect. Statement (I) is incorrect but Statement (II) is correct.

Q.4

Veterinary Pharmacology and Toxicology- ICAR JRF/SRF 2024 (Q.82)

Statement Based +4 −1

Given below are two statements

Statement (I) : In the basic quinolone structure, the carboxyl group at position 3 and the ketone at position 4 are necessary for the antibacterial activity.

Statement (II) : The fluorine at position 6 differentiates the quinolones from the fluoroquinolones and accounts for the improved gram-negative and gram-positive activity over the nonfluorinated quinolones, increased potency, and increased entry into bacteria.

In light of the above statements, choose the most appropriate answer from the options given below.

Both Statement (|) and Statement (I) are correct Both Statement (I) and Statement (II) are incorrect Statement (I) is correct but Statement (II) is incorrect. Statement (I) is incorrect but Statement (II) is correct.