Therapy of Ovarian Cysts in Bovines: Gonadorelin (synthetic Gonadotropin-Releasing Hormone / GnRH decapeptide, administered at $100\text{--}250\ \mu\text{g}$ IM) is the drug of choice for treating cystic ovarian disease (follicular cysts) in dairy cattle.
Mechanism of Action: Gonadorelin stimulates anterior pituitary gonadotrophs to release a surge of Luteinizing Hormone (LH). The LH surge induces luteinization of the persistent anovulatory follicular cyst into a functional corpus luteum, which can then be lysed 9–14 days later with $\text{PGF}_{2\alpha}$ to re-establish normal estrous cyclicity.
Correct option: (4) Gonadorelin
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ICAR JRF Veterinary Pharmacology And Toxicology 29 Jun 2024Shift 1
MCQ (Single Correct)+4−1
Which one of the given choices is GnRH antagonist:
Pharmacology of Danazol: Danazol is a synthetic isoxazole derivative of ethisterone (an attenuated androgen) that functions as an antigonadotropin and functional GnRH / gonadotropin antagonist/suppressor.
Mechanism of Action: It binds to steroid receptors and exerts powerful negative feedback inhibition on the hypothalamic-pituitary-gonadal axis, suppressing pulsatile release of GnRH, LH, and FSH.
Superagonists: Buserelin, Leuprorelin, and Goserelin are synthetic GnRH agonists (superagonists) with substitutions at positions 6 and 10 that initially stimulate gonadotropin release.
Correct option: (4) Danazol
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