Q.38
Which of the following CNS neurotransmitter is excitatory on the individual neurons and causes a decrease in potassium
conductance
EXPLANATION
Cholinergic Transmission: Muscarinic & Nicotinic Agonists, Anticholinesterases & Antidotes
- Central Neurotransmission of Acetylcholine (ACh):
- In the central nervous system, acetylcholine acting on muscarinic receptors ($M_1$ subtype) produces slow, prolonged excitatory postsynaptic potentials (EPSPs).
- The biochemical mechanism involves $G_q$-protein activation, which closes voltage-gated potassium channels (the M-current / $I_M$), causing a decrease in potassium conductance ($g_{K^+}$).
- Decreased outward $K^+$ efflux leads to membrane depolarization and sustained neuronal excitation.
- (GABA and Glycine increase chloride conductance; Dopamine acts through D1/D2 GPCRs).
- nalysis:
- (Acetylcholine): Correct.
Correct option: (4) Acetylcholine
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