Q.72
Which of the following bacterial pathogens causes Guillain-Barre Syndrome through the consumption of raw milk?
EXPLANATION
Milk-Borne Bacterial Pathogens & Zoonoses: Campylobacter jejuni, Listeria, E. coli O157:H7 & S. aureus
- Campylobacter jejuni and Guillain-Barré Syndrome (GBS):
- Pathogen Characteristics:
- Campylobacter jejuni is a microaerophilic, curved Gram-negative motile bacterium shed by dairy cattle and transmitted via consumption of raw, unpasteurized milk.
- Pathogenesis of GBS:
- It is the leading antecedent trigger of Guillain-Barré Syndrome (GBS), an acute autoimmune polyneuropathy characterized by ascending motor paralysis.
- Arises from molecular mimicry: Antibodies directed against the core lipooligosaccharide (LOS) of C. jejuni cross-react with human peripheral nerve gangliosides (GM1, GD1a), causing autoimmune demyelination.
- Conclusion: Campylobacter jejuni (Option 3).
Correct option: (3) Campylobacter jejuni
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