Q.116
Fish Physiology and Biochemistry- ICAR JRF/SRF 2024
MCQ (Single Correct) +4 −1
NADH, generated in energy yielding reactions of cytosol, is transported to mitochondria through
  • Transport of Cytosolic Reducing Equivalents into Mitochondria:
  • The inner mitochondrial membrane is strictly impermeable to $NADH$ produced in the cytosol during glycolysis.
  • Glycerol-3-Phosphate Shuttle:
  • Cytosolic glycerol-3-phosphate dehydrogenase oxidizes $NADH$ to $NAD^+$, reducing dihydroxyacetone phosphate (DHAP) to glycerol-3-phosphate (G3P).
  • G3P diffuses across the outer mitochondrial membrane.
  • Mitochondrial glycerol-3-phosphate dehydrogenase (located on the outer surface of the inner membrane) re-oxidizes G3P back to DHAP, transferring electrons to an enzyme-bound $FAD$ to form $FADH_2$.
  • $FADH_2$ passes electrons directly to ubiquinone (coenzyme Q) in the electron transport chain.
    • nalysis:

  • (Glycerol-3-phosphate shuttle): Correct.
Correct option: (4) Glycerol-3-phosphate shuttle

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