Q.36
--- are the enzymes responsible for the conversion of PUFAs to prostaglandins.
- Biosynthesis of Prostaglandins from PUFAs:
- Prostaglandins are bioactive eicosanoids synthesized from 20-carbon polyunsaturated fatty acids (Arachidonic acid, $20:4\, n-6$, or Eicosapentaenoic acid, $20:5\, n-3$).
- Cyclooxygenases (COX / Prostaglandin-Endoperoxide Synthase): Catalyze the rate-limiting dual enzymatic steps:
- Cyclooxygenase activity: Bis-oxygenation and cyclization of arachidonic acid to Prostaglandin $G_2$ ($PGG_2$).
- Peroxidase activity: Reduction of $PGG_2$ to Prostaglandin $H_2$ ($PGH_2$), which is then converted by tissue isomerases into prostaglandins ($PGE_2, PGF_{2\alpha}, PGD_2$), prostacyclins, and thromboxanes.
- Correct Option: Option 1 (Cyclooxygenases).
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