Q.120
Which of the following toxin causes Mad Honey Poisoning?
EXPLANATION
Food Toxins & Chemical Contaminants: Aflatoxins, Grayanotoxins (Mad Honey), Scombroid & Marine Toxins
- Etiology of Mad Honey Poisoning (Honey Intoxication):
- Natural Neurotoxin:
- Caused by the ingestion of wild honey produced from the nectar and pollen of plants belonging to the family Ericaceae, predominantly Rhododendron luteum and Rhododendron ponticum.
- Contains polyhydroxylated cyclic diterpenes known as Grayanotoxins (andromedotoxins).
- Grayanotoxins bind voltage-gated sodium channels in cell membranes, preventing inactivation and causing profound bradycardia, hypotension, and central nervous depression.
- Conclusion: Grayanotoxins (Option 2).
Correct option: (2) Grayanotoxins
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