The Mitotic division is terminated by | Agrigyan

Q.106

Genetics & Plant Breeding - ICAR JRF/SRF 2024

MCQ (Single Correct) +4 −1

The Mitotic division is terminated by

Phosphorylation of substrates by M Phase kinase Dephosphorylation of substrates by M Phase kinase Phosphorylation of substrates by Phosphatases Dephosphorylation of substrates by Phosphatases Correct

Mitotic Exit Regulation:
Mitosis is initiated by extensive phosphorylation of cellular substrates by M-phase Cyclin-dependent kinase (CDK1/Cyclin B).
Termination of mitotic division and entry into cytokinesis/telophase strictly require the dephosphorylation of mitotic substrates by specific phosphatases (such as Cdc14, PP1, and PP2A) following the targeted proteasomal destruction of Cyclin B by the Anaphase-Promoting Complex/Cyclosome (APC/C). (Correct answer: Option 4)

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