Q.87
What is the advantage of probing a transcriptome with mRNAs bound to ribosomes?
- Translatome and Ribosome-Bound mRNA (Polysome Profiling):
- Total cellular mRNA reflects steady-state transcript abundance, but not all transcribed mRNAs are translated into protein due to microRNA-mediated translational repression, secondary structures, or storage in P-bodies.
- Isolating ribosome-bound mRNAs (polysomal RNA) captures the active translatome, providing an accurate, direct reflection of the mRNAs that are actively being translated into functional proteins at that specific physiological state.
Correct option: (2) mRNA molecules isolated from ribosomes represent those that are actively being translated into proteins
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