Q.55
Match List with List-I a ae
Choose the correct answer from the options given below :
|
List - I
|
List - II
|
||
|---|---|---|---|
| A | IL-1 IL-1 | I | Stimulates T cell proliferation and cytotoxicity Stimulates T cell proliferation and cytotoxicity |
| B | IL-2 IL-2 | II | Key mediator of cell-mediated immune responses Key mediator of cell-mediated immune responses |
| C | 1L-4 1L-4 | LT | Proinflammatory mediator and a Th2 cell stimulator Proinflammatory mediator and a Th2 cell stimulator |
| D | interferon-gamma interferon-gamma | IV | Stimulates the growth and differentiation of B cells Stimulates the growth and differentiation of B cells |
- Cytokine Functions in Immunology:
- IL-1: Secreted by macrophages; acts as a (III) Proinflammatory mediator inducing fever, acute-phase proteins, and co-stimulating Th2 development.
- IL-2 (T cell growth factor): Secreted by activated Th1 cells; (I) Stimulates T cell proliferation and cytotoxicity (drives clonal expansion of cytotoxic T cells and NK cells).
- IL-4: Secreted by Th2 cells; (IV) Stimulates growth, activation, and differentiation of B cells, driving immunoglobulin class-switching to IgE and IgG1.
- Interferon-gamma (IFN-$\gamma$): Secreted by Th1 and NK cells; (II) Key mediator of cell-mediated immunity, strongly activating macrophages for intracellular pathogen clearance.
- Matching Result:
- (III), (B)-(I), (C)-(IV), (D)-(II). Hence, Option 2 is correct.
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