Q.103
Glomerular filtration of a drug is affected by its
- Determinants of Glomerular Filtration: In renal elimination, glomerular filtration of a drug is fundamentally governed by its plasma protein binding.
- Free Drug Fraction: Only the unbound (free) drug fraction in plasma is small enough to pass through the fenestrated glomerular capillary endothelial pores and basement membrane podocyte slit diaphragms ($cutoff \sim 60\text{ kDa}$). Drug molecules bound to large plasma proteins (albumin, $\alpha_1$-acid glycoprotein) cannot be filtered.
Correct option: (2) Plasma protein binding
Explanation not matching this question?
क्या व्याख्या इस प्रश्न से मेल नहीं खा रही?
Report
Want to practice this paper in exam conditions?
क्या आप परीक्षा जैसे माहौल में अभ्यास करना चाहते हैं?
Test yourself in 5-question batch format with timer and hidden answers.
5-प्रश्नों के बैच फॉर्मैट, टाइमर और छिपे उत्तरों के साथ खुद को परखें।
Start Practice Mode →
प्रैक्टिस टेस्ट मोड शुरू करें →