Q.37
Which one of the following options is a Catechol-O-Methyl transferase inhibitor:
- Enzymatic Degradation of Catecholamines and COMT Inhibition:
- Catechol-O-Methyltransferase (COMT) catalyzes the transfer of a methyl group from S-adenosylmethionine to a hydroxyl group of catecholamines (dopamine, epinephrine, norepinephrine) and levodopa.
- Entacapone (and Tolcapone) is a selective, reversible COMT inhibitor used in neuropharmacology to prevent peripheral breakdown of levodopa, increasing central dopamine availability.
- Selegiline and Rasagiline are MAO-B inhibitors; Clorgyline is a MAO-A inhibitor.
- nalysis:
- (Entacapone): Correct COMT inhibitor.
Correct option: (3) Entacapone
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