Q.35
Veterinary Surgery and Radiology- ICAR JRF/SRF 2024
MCQ (Single Correct) +4 −1
The primary endogenous substrate for nitric oxide synthase is
  • Biosynthesis of Endogenous Nitric Oxide (NO):
  • Nitric oxide is an endothelial-derived relaxing factor (EDRF) synthesized by the family of Nitric Oxide Synthase (NOS) enzymes (eNOS, nNOS, iNOS).
  • The reaction requires molecular oxygen, NADPH, and tetrahydrobiopterin ($BH_4$), using L-Arginine as the obligatory amino acid substrate:
$$\mathbf{L\text{-Arginine}} + \text{NADPH} + H^+ + O_2 \xrightarrow{\text{NOS}} \mathbf{\text{Nitric Oxide (NO)}} + L\text{-Citrulline} + \text{NADP}^+$$
  • nalysis:
  • (Arginine): Correct primary substrate.

Correct option: (4) Arginine

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