Q.76
This drug causes penile prolapse in horses
EXPLANATION
Sedatives & Tranquilizers: Phenothiazines (Acepromazine Penile Prolapse in Equines) & Alpha-2
- Phenothiazine Complication in Equines: Acepromazine maleate is notorious for inducing persistent penile prolapse (penile protrusion), paraphimosis, and priapism in horses, particularly stallions.
- Mechanism: Acepromazine produces peripheral $\alpha_1$-adrenergic antagonism, which relaxes the retractor penis muscle and dilates internal pudendal vessels. In stallions, prolonged vasodilation can lead to thrombosis of the corpus cavernosum penis, permanent paralysis, and required phallectomy.
Correct option: (3) Acepromazine
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