Q.1
Which of the following statement is not true?
- Dietary Cation-Anion Difference (DCAD) and Milk Fever Prevention:
- Parathyroid hormone (PTH) acts on bone and kidney to maintain plasma calcium homeostasis:
- Metabolic Acidosis (Acidotic state): Induced by feeding anionic salts (negative DCAD diets). Acidosis optimizes the conformation of PTH receptors, markedly increasing the sensitivity of bone osteoclasts to PTH and promoting bone calcium resorption.
- Metabolic Alkalosis (Alkalotic state): Induced by excess dietary cations ($K^+, Na^+$). Alkalosis induces a refractory state where bone receptors become insensitive to PTH, impairing calcium mobilization and precipitating hypocalcemia (milk fever).
- Therefore, the assertion that an alkalotic state increases bone sensitivity to PTH is scientifically false (not true).
- nalysis:
- Statement 1 is incorrect/not true, hence the correct answer.
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