1
The hammerhead ribozyme is one of the most commonly used ribozymes in technology. Which of the following statements is
true about its function and structure?
EXPLANATION
DNA Repair Pathways, Ribosomes & Catalytic RN
- Hammerhead Ribozyme Mechanism: The hammerhead ribozyme is a small catalytic RNA motif comprising three base-paired helical stems surrounding a conserved core.
- Cleavage Chemistry: It catalyzes a site-specific phosphodiester bond transesterification wherein the 2'-hydroxyl oxygen attacks the adjacent 3'-phosphorus in an in-line $S_N2$ nucleophilic substitution, producing a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus without requiring a protein cofactor.
- Conclusion: Option 2 correctly identifies its cleavage mechanism.
Correct option: (2) It cleaves RNA sequences using a water molecule in a mechanism similar to protein enzymes.
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