Q.1
Given below are two statements, one is labelled as Assertion (A) and other one labelled as Reason (R).
Assertion (A) : B-lactam antibiotics are given in combination with clavulanic acid
Reason (R) : Clavulanic acid binds with B-lactamase with a high affinity, inhibits it and prevents it to act on the B-lactam
antibiotics.
In light of the above statements, choose the correct answer from the options given below.
- Assertion (A) is True: $\beta$-lactam antibiotics (e.g., amoxicillin) are co-prescribed with clavulanic acid (e.g., Co-amoxiclav / Augmentin) to restore antibacterial efficacy against resistant pathogen strains.
- Reason (R) is True & Explains (A): Clavulanic acid is a suicide inhibitor (mechanism-based irreversible inhibitor) with structural homology to the $\beta$-lactam nucleus. It binds to the catalytic serine residue of bacterial $\beta$-lactamase enzymes, forming a stable covalent acyl-enzyme adduct that permanently inactivates the enzyme and protects the partner antibiotic.
- Conclusion: Both (A) and (R) are true and (R) is the correct explanation of (A).
Correct option: (1) Both (A) and (R) are true and (R) is the correct explanation of (A)
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