Q.1
Read the following statements-
(A) . Acetyl Co-Ais the positive allosteric modulator of Pyruvate decarboxylase.
(B) . Thiamine pyrophosphate is an essential co-factor of pyruvate decarboxylase
(C) . Pyruvate decarboxylase is universally present in plants and animals.
(D) . Pyruvate decarboxylase converts pyruvate to acetaldehyde and CO
(E) . The decarboxylation reaction by pyruvate decarboxylase is an irreversible reaction
Choose the correct answer from the options given below:
- Statement (B) is Correct: Pyruvate decarboxylase requires Thiamine pyrophosphate (TPP) and $\text{Mg}^{2+}$ as essential cofactors to stabilize the carbanion intermediate.
- Statement (D) is Correct: Catalyzes the decarboxylation of pyruvate to acetaldehyde and carbon dioxide:
- Statement (E) is Correct: The decarboxylation reaction is physiologically irreversible.
- Why (A) and (C) are Incorrect: Acetyl-CoA is the allosteric activator of pyruvate carboxylase (gluconeogenesis), not decarboxylase. Pyruvate decarboxylase is active in plants, fungi, and yeasts for ethanol fermentation, but is absent in animals.
- Conclusion: (B), (D), and (E) only are correct.
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