Calf Rennet (Bovine Chymosin): Exhibits the highest Milk Clotting Activity to Proteolytic Activity ratio ($MCA/PA$). It has exquisite specificity for the single peptide bond $Phe_{105}-Met_{106}$ of $\kappa$-casein with minimal general unspecific proteolysis.
Bacterial rennets (e.g., from Bacillus subtilis) and plant rennets (ficin, papain, bromelain) have excessively high general proteolytic activity ($PA$), which causes weak curds, protein loss in whey, and bitter peptide accumulation.
Correct Option: Option 2 (Calf rennet).
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