Q.1
Match List-I with List-II:
Choose the correct answer from the options given below:
|
List - I
सूची - I
*Streptomyces* and related actinobacteria
List-I (*Streptomyces* and related actinobacteria
|
List - II
सूची - II
Antibiotic produced
List-II (Antibiotic produced
|
||
|---|---|---|---|
| A | *Streptomyces fradiae* *Streptomyces fradiae* | I | Amphotericin B Amphotericin B |
| B | *Streptomyces noursei* *Streptomyces noursei* | II | Chloramphenicol Chloramphenicol |
| C | *Streptomyces nodosus* *Streptomyces nodosus* | III | Streptomycin Streptomycin |
| D | *Streptomyces griseus* *Streptomyces griseus* | IV | Neomycin Neomycin |
| E | *Streptomyces venezuelae* *Streptomyces venezuelae* | V | Nystatin Nystatin |
- Antibiotics Produced by Actinobacteria (Streptomyces spp.):
- Pair-by-Pair Matching:
- Streptomyces fradiae $\rightarrow$ (IV) Neomycin: An aminoglycoside antibiotic that binds to the 30S ribosomal subunit, misreading mRNA codons.
- Streptomyces noursei $\rightarrow$ (V) Nystatin: A polyene antifungal antibiotic that binds to ergosterol in fungal plasma membranes.
- Streptomyces nodosus $\rightarrow$ (I) Amphotericin B: A potent systemic polyene antifungal agent that forms transmembrane pores by binding ergosterol.
- Streptomyces griseus $\rightarrow$ (III) Streptomycin: The landmark aminoglycoside antibiotic discovered by Albert Schatz and Selman Waksman (1943) that targets tuberculosis.
- Streptomyces venezuelae $\rightarrow$ (II) Chloramphenicol: Broad-spectrum antibiotic inhibiting peptidyl transferase on the 50S ribosomal subunit.
- Correct Choice: Option 4 matches (A)-(IV), (B)-(V), (C)-(I), (D)-(III), (E)-(II).
Correct option: (4) (A) (IV), (B) - (V), (C)- (1), (D) = (I), (E) — (I)
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