Choose the correct answer from the options given below:
|
List - I
सूची - I
Strategy
List-I (Strategy
|
List - II
सूची - II
Mode of Action
List-II (Mode of Action
|
||
|---|---|---|---|
| A | Ribozyme / RNase P Ribozyme / RNase P | I | Interferes with replication Interferes with replication |
| B | Coat Protein Coat Protein | II | Binds to RNA preventing function Binds to RNA preventing function |
| C | cDNA of RNA satellite cDNA of RNA satellite | III | Interferes with uncoating Interferes with uncoating |
| D | Antisense RNA Antisense RNA | IV | Cleavage of RNA genome Cleavage of RNA genome |
- Ribozyme / RNase P $
ightarrow$ (IV) Cleavage of RNA genome: Catalytic RNA molecules that specifically bind target viral RNA through complementary base pairing and cleave phosphodiester bonds.
- Coat Protein $
ightarrow$ (III) Interferes with uncoating: Transgenic expression of viral coat protein (CP-mediated resistance) prevents the disassembly and uncoating of invading virions upon initial cell entry.
- cDNA of RNA satellite $
ightarrow$ (I) Interferes with replication: Satellite RNAs attenuate symptom severity by competing with helper virus genomic RNA for viral replicase machinery.
- Antisense RNA $
ightarrow$ (II) Binds to RNA preventing function: Hybridizes with complementary sense viral mRNA or genomic RNA, blocking translation and triggering enzymatic degradation.
Correct option: (4) (A) - (IV), (B) - (MN), (C)~ (), (B) - (HN)