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What is the most common cause of acute kidney failure due to nephrosis?
EXPLANATION
Renal Pathology
- Pathogenesis of Acute Tubular Necrosis (Nephrosis):
- Nephrosis refers to non-inflammatory degenerative lesions and necrosis of the renal tubular epithelium.
- Nephrotoxins are the leading cause:
- Heavy metals (arsenic, lead, mercury).
- Pharmaceuticals (aminoglycoside antibiotics like gentamicin, amphotericin B, NSAIDs).
- Plant and fungal nephrotoxins (oak tannins, oxalates, ochratoxin A).
- Toxicants concentrate within renal proximal tubular cells, directly causing cellular swelling, mitochondrial dysfunction, and acute tubular necrosis leading to acute oliguric renal failure.
- nalysis:
- (Nephrotoxins): Correct primary cause.
Correct option: (3) Nephrotoxins
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