Q.1
Induced Pluripotent Stem cells (PSCs) can be produced by transfection of somatic cells with genes
- Cellular Reprogramming to Pluripotency:
- First pioneered by Shinya Yamanaka (2006, Yamanaka factors: Oct4, Sox2, Klf4, c-Myc) and James Thomson (2007):
- Differentiated adult somatic cells are reprogrammed into pluripotent stem cells (iPSCs) by the ectopic transfection of defined core transcription factor cocktails:
(The classic Thomson reprogramming gene cocktail).
- nalysis:
- (Pou5f1, Sox2, Nanog, Lin28): Correct factor combination.
Correct option: (1) PouSft, Sox2, Nanog, Lin28.
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