Q.1
In phase one reaction of metabolism of xenobiotics, the reducing power is provided by
- Phase I Xenobiotic Metabolism: Catalyzed by the microsomal Cytochrome P450 monooxygenase system in the smooth endoplasmic reticulum:
- Reducing Equivalents: The required electrons/reducing power are supplied by NADPH, which transfers electrons to cytochrome P450 via the flavoprotein NADPH-cytochrome P450 reductase (containing FAD and FMN).
- Source of NADPH: Mainly generated via the pentose phosphate pathway (HMP shunt).
Correct option: (1) NADPH
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