Q.1
Which isoenzyme of LDH is present in heart
- Quaternary Structure of Lactate Dehydrogenase (LDH):
- LDH is a tetrameric enzyme composed of two distinct polypeptide subunits: $M$ (Muscle) and $H$ (Heart), assembling into five distinct isozymes:
- LDH-1 ($H_4$ / $HHHH$): Heart muscle and erythrocytes ($\gt 90\%$ of cardiac LDH).
- LDH-2 ($H_3M$): Reticuloendothelial system and heart.
- LDH-3 ($H_2M_2$): Lungs and spleen.
- LDH-4 ($HM_3$): Kidneys and pancreas.
- LDH-5 ($M_4$ / $MMMM$): Skeletal muscle and liver.
- nalysis:
- (HHHH): Correct cardiac LDH isozyme.
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