1
Which of the following represents a replication-deficient adenoviral vector based on the simian adenovirus type Y25 that has
been used for producing several vaccines, including COVID-19?
EXPLANATION
Cloning & Expression Vectors
- ChAdOx1 Vector: Chimpanzee Adenovirus Oxford 1 (ChAdOx1) is a replication-deficient adenoviral vector derived from simian adenovirus type Y25.
- Replication Deficiency: Engineered by deleting the essential early viral genes E1 and E3, preventing viral replication inside human host cells while allowing high-level antigen expression.
- Vaccine Application: Used as the vector platform by the Jenner Institute (Oxford University) and AstraZeneca/Serum Institute of India to deliver the SARS-CoV-2 spike protein gene (AZD1222 / Covishield).
Correct option: (1) ChAdOx1
Explanation not matching this question?
क्या व्याख्या इस प्रश्न से मेल नहीं खा रही?
Report
Want to practice this paper in exam conditions?
क्या आप परीक्षा जैसे माहौल में अभ्यास करना चाहते हैं?
Test yourself in 5-question batch format with timer and hidden answers.
5-प्रश्नों के बैच फॉर्मैट, टाइमर और छिपे उत्तरों के साथ खुद को परखें।
Start Practice Mode →
प्रैक्टिस टेस्ट मोड शुरू करें →