Q.2
The base hypoxanthine in the nucleotide inosine can hydrogen bond with
EXPLANATION
Translation Mechanisms, Ribosome Subunits, Polysome Profiling & Translational Ribosomal Stalling
- Wobble Hypothesis & Inosine: Inosine is a modified purine nucleoside containing the base hypoxanthine, formed by post-transcriptional deamination of adenine in tRNA anticodons.
- Wobble Base Pairing: When present at the wobble position (the first base of the anticodon, $5'$ position), inosine can form stable, non-Watson-Crick hydrogen bonds with three different bases in mRNA codons:
- Uracil (U) (2 hydrogen bonds)
- Cytosine (C) (2 hydrogen bonds)
- Adenine (A) (2 hydrogen bonds)
- It does not pair with Guanine (G) due to severe steric hindrance and electrostatic repulsion between purine ring substituents.
Correct option: (4) U, C, and A,
Explanation not matching this question?
क्या व्याख्या इस प्रश्न से मेल नहीं खा रही?
Report
Want to practice this paper in exam conditions?
क्या आप परीक्षा जैसे माहौल में अभ्यास करना चाहते हैं?
Test yourself in 5-question batch format with timer and hidden answers.
5-प्रश्नों के बैच फॉर्मैट, टाइमर और छिपे उत्तरों के साथ खुद को परखें।
Start Practice Mode →
प्रैक्टिस टेस्ट मोड शुरू करें →