Q.1
Given below are two statements, one is labelled as Assertion (A) and other one labelled as Reason (R).
Assertion (A) : Cirrhosis is the term used for chronic inflammation of liver.
Reason (R) : It is characterized by massive fibrosis along with regeneration of hepatocytes.
In light of the above statements, choose the correct answer from the options given below.
EXPLANATION
Pathology of Digestive System: Primary Tympany Bloat, Rumenitis, Enteritis & Hepatic Cirrhosis
- Definition and Triad of Cirrhosis:
- Cirrhosis is the irreversible end-stage morphological alteration of chronic liver injury characterized by:
- Diffuse, massive bridging fibrosis (deposition of type I and III collagen by activated hepatic stellate cells).
- Parenchymal destruction and formation of regenerative nodules of hepatocytes lacking normal central-vein architecture.
- Structural vascular reorganization and architectural distortion leading to portal hypertension and hepatic insufficiency.
- nalysis:
- Both (A) and (R) are true, and (R) provides the definitive pathological explanation of (A). Hence, Option 1 is correct.
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