1
Fibrinoid necrosis develops, when the wall of blood vessels gets deposited with
(A) . Immunoglobulins
(B) . Complement
(C) . Plasma proteins
(D) . Fibrin
Choose the correct answer from the options given below:
EXPLANATION
Hypersensitivity Reactions in Tissue Patholog
- Mechanism of Fibrinoid Necrosis: Fibrinoid necrosis is a specialized form of tissue death typically involving the walls of blood vessels (vasculitis, malignant hypertension, Arthus reaction, polyarteritis nodosa).
- Depositional Components: Arises when severe immune-complex deposition (Type III hypersensitivity) triggers complement activation and neutrophilic infiltration, disrupting endothelial integrity. Circulating (A) Immunoglobulins, (B) Complement components ($C3$, $C1q$), and (C) Plasma proteins leak into the vessel wall alongside extravasated (D) Fibrin, polymerizing into an amorphous, bright pink, refractile smudgy deposit on H&E staining resembling fibrin.
Correct option: (3) (A), (B), (C) and (D).
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