Animal Reproduction - Gynaecology and Obstetrics- ICAR JRF/SRF 2024

• Pathogenesis of Streptococcus suis in Swine:
• Streptococcus suis (particularly serotypes 1 and 2) is a major encapsulated zoonotic bacterial pathogen of pigs.
• In neonatal and weaned piglets, colonization of palatine tonsils is followed by bacteremia and acute septicemia.
• The pathogen crosses vascular barriers to localize in:

• Meninges: Suppurative meningitis, lateral recumbency, paddling leg movements.
• Synovial Joints: Polyarthritis and joint ill (swollen hocks and stifles).
• Endocardium: Vegetative valvular endocarditis.
  • nalysis:

• (Streptococcus suis type 1): Correct pathogen responsible for this systemic syndrome.

• Systemic Inflammatory Response in Neonatal Farm Animals:
• Neonatal septicemia (joint ill, navel ill, colisepticemia) in calves, foals, and piglets results from opportunistic bacterial invasion (e.g., E. coli, Salmonella) following failure of passive transfer (FPT) of colostral immunoglobulins.
• Cardiovascular and Thermoregulatory Signs:
• The release of pyrogenic cytokines (IL-1, TNF-$\alpha$) and bacterial endotoxins (LPS) resets the hypothalamic thermostat, producing marked elevated body temperature (pyrexia / hyperthermia) in early stages, accompanied by depression, injected scleral vessels, and loss of suckle reflex.
• nalysis:
• (Elevated body temperature): Correct diagnostic clinical sign.

Correct option: (2) Elevated body temperature