• Pharmacodynamics of Antacids:
• Antacids (aluminum hydroxide, magnesium hydroxide, calcium carbonate) are basic compounds that chemically react with gastric hydrochloric acid ($HCl$) to form neutral salts and water.
• By instantly raising intragastric pH above $3.5 - 4.0$, antacids neutralize free acidity and inactivate proteolytic pepsin.
• Their primary and most immediate clinical utility is the prompt relief of ulcer pain within minutes of administration.
• (Definitive ulcer healing and relapse prevention are achieved with H2-receptor antagonists or proton pump inhibitors like omeprazole).
• nalysis:
• (Prompt relief of pain): Correct.

Correct option: (1) Prompt relief of pain

• Ruminal Metabolism and Toxic Activation:
• Cyanogenic Glycosides (e.g., dhurrin in immature sorghum/jowar, linamarin in linseed/flax):
• Intact cyanogenic glycosides are relatively non-toxic when consumed.
• In the rumen, microbial $\beta$-glucosidase and hydroxynitrile lyase enzymes rapidly hydrolyze the glycosides, liberating free, lethal Hydrocyanic Acid (HCN / Cyanide):

• Free cyanide binds ferric iron ($Fe^{3+}$) in cytochrome oxidase, arresting cellular respiration. Hence, ruminal metabolism directly intensifies its toxicity.
• nalysis:
• (Cyanogenic glycosides): Correct.

Correct option: (3) Cyanogenic glycosides

• Pathogenesis of Secondary Photosensitization:
• Assertion (A): Photosensitization is a photodynamic reaction wherein an absorbing molecule in cutaneous capillaries is activated by UV/sunlight ($320 - 400\text{ nm}$), producing reactive oxygen species that induce severe cutaneous necrosis and dermatitis. (True).
• Reason (R): In ruminants, Phylloerythrin is a porphyrin breakdown product of chlorophyll produced by rumen microbes and normally excreted in bile. Diffuse liver injury (facial eczema from sporidesmin, lantana toxicity, pyrrolizidine alkaloids) impairs biliary excretion, causing phylloerythrin to spill into dermal blood circulation where sunlight activates it. (True).
• nalysis:
• Both (A) and (R) are true, and (R) is the precise physiological cause of (A). Hence, Option 1 is correct.