Dietary Cation-Anion Difference (DCAD) and Milk Fever Prevention:
Parathyroid hormone (PTH) acts on bone and kidney to maintain plasma calcium homeostasis:
Metabolic Acidosis (Acidotic state): Induced by feeding anionic salts (negative DCAD diets). Acidosis optimizes the conformation of PTH receptors, markedly increasing the sensitivity of bone osteoclasts to PTH and promoting bone calcium resorption.
Metabolic Alkalosis (Alkalotic state): Induced by excess dietary cations ($K^+, Na^+$). Alkalosis induces a refractory state where bone receptors become insensitive to PTH, impairing calcium mobilization and precipitating hypocalcemia (milk fever).
Therefore, the assertion that an alkalotic state increases bone sensitivity to PTH is scientifically false (not true).
nalysis:
Statement 1 is incorrect/not true, hence the correct answer.
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