Q114: Irreversible cell injury is seen in - Haemodynamic Derangements, Degeneration and Necrosis - Veterinary Pathology- ICAR JRF/SRF 2024 | Agrigyan

• Reversibility of Cellular Injury:
• Irreversible Injury: When cellular injury progresses past the 'point of no return'—characterized by permanent mitochondrial dysfunction (inability to synthesize ATP) and profound plasma/lysosomal membrane damage—the outcome is irreversible cell death via Necrosis (or apoptosis).
• Reversible Injury Patterns:
• Acute cellular swelling (cloudy swelling): Early reversible failure of the plasma membrane $\text{Na}^+/\text{K}^+$ ATPase pump allowing $\text{Na}^+$ and water influx.
• Hydropic degeneration: Advanced reversible vacuolar swelling.
• Fatty change (steatosis): Reversible accumulation of triglycerides within the cytoplasm.

Correct option: (3) Necrosis