Q114: According to Wobble hypothesis GCI present in anticodon arm of... - Molecular Biology & Veterinary Biotechnology - ICAR AIEEA PG 2024 - Animal Biotechnology | Agrigyan

Inosine (I) at the 5' wobble position of the tRNA anticodon ($5'\text{-I-C-G-}3'$) can base-pair with U, C, or A at the 3' position of mRNA codons. Codons are read 5' to 3', so compatible mRNA codons pairing with $5'\text{-I-C-G-}3'$ are $5'\text{-C-G-U-}3'$, $5'\text{-C-G-C-}3'$, and $5'\text{-C-G-A-}3'$. Thus, (A) and (C) only are correctly matching codons.