Veterinary Medicine- ICAR JRF/SRF 2024

• Mechanisms of Jaundice (Icterus):
• Hemolytic (Pre-Hepatic) Jaundice: Arises from excessive intravascular or extravascular breakdown of erythrocytes, overwhelming the hepatic capacity for bilirubin conjugation:
• Caused by hemoparasites (Babesia, Anaplasma), isoimmune hemolytic anemia, and Bacterial toxins (e.g., Clostridium perfringens type A alpha-toxin phospholipase C, Leptospira interrogans hemolysins) that directly lyse erythrocyte cell membranes.
• Biliary calculi cause post-hepatic obstructive jaundice; hepatic fibrosis causes hepatic jaundice.
• nalysis:
• (Bacterial toxins): Correct cause of hemolytic icterus.

Correct option: (3) Bacterial toxins

• Differential Diagnosis of Respiratory Bleeding:
• Hemoptysis: The coughing up of blood or blood-stained sputum originating specifically from the lower respiratory tract—the Lungs (pulmonary parenchyma, bronchi, or alveoli) (e.g., pulmonary abscessation, vena cava thrombosis with pulmonary thromboembolism, or tuberculosis).
• Epistaxis: Bleeding originating from the nasal cavity, ethmoid turbinates, or guttural pouch.
• Hematemesis: Vomiting of blood originating from the stomach.
• nalysis:
• (Lungs): Correct anatomical source.

Correct option: (4) Lungs

• Pathomorphology of Pulmonary Emphysema:
• Characterized by the abnormal, permanent enlargement and overdistension of airspaces distal to the terminal bronchioles, accompanied by destructive rupture of alveolar septal walls.
• Loss of alveolar surface area and elastic recoil leads to air trapping, expiratory dyspnea, and formation of subpleural bullae (bullous emphysema) or dissection of air into interlobular septa (interstitial emphysema common in cattle due to lack of collateral ventilation).
• nalysis:
• (Overdistension of alveoli with rupture of alveolar walls): Correct definition.

Correct option: (2) Overdistension of alveoli with rupture of alveolar walls

• Pathogenesis of Acute Tubular Necrosis (Nephrosis):
• Nephrosis refers to non-inflammatory degenerative lesions and necrosis of the renal tubular epithelium.
• Nephrotoxins are the leading cause:
• Heavy metals (arsenic, lead, mercury).
• Pharmaceuticals (aminoglycoside antibiotics like gentamicin, amphotericin B, NSAIDs).
• Plant and fungal nephrotoxins (oak tannins, oxalates, ochratoxin A).
• Toxicants concentrate within renal proximal tubular cells, directly causing cellular swelling, mitochondrial dysfunction, and acute tubular necrosis leading to acute oliguric renal failure.
• nalysis:
• (Nephrotoxins): Correct primary cause.

Correct option: (3) Nephrotoxins