35 Veterinary Medicine- ICAR JRF/SRF 2024 MCQ (Single Correct) The primary endogenous substrate for nitric oxide synthase is A Acetylcholine Correct Incorrect B Citruline Correct Incorrect C Angiotensinogen Correct Incorrect D Arginine Correct Incorrect Check Answer EXPLANATION Vasoactive Peptides & Mediators: Kinins, Serotonin, Nitric Oxide & Endothelin Biosynthesis of Endogenous Nitric Oxide (NO):Nitric oxide is an endothelial-derived relaxing factor (EDRF) synthesized by the family of Nitric Oxide Synthase (NOS) enzymes (eNOS, nNOS, iNOS).The reaction requires molecular oxygen, NADPH, and tetrahydrobiopterin ($BH_4$), using L-Arginine as the obligatory amino acid substrate: $$\mathbf{L\text{-Arginine}} + \text{NADPH} + H^+ + O_2 \xrightarrow{\text{NOS}} \mathbf{\text{Nitric Oxide (NO)}} + L\text{-Citrulline} + \text{NADP}^+$$ nalysis:(Arginine): Correct primary substrate. Correct option: (4) Arginine Explanation not matching this question? क्या व्याख्या इस प्रश्न से मेल नहीं खा रही? Report Prev Next